/Tag: Nephrology
4 09, 2019

Acute Kidney Injury (AKI): Management and Outcome

By |2020-02-03T11:46:33+00:00September 4th, 2019|Tags: , , , |

In my previous article, I explained the types, causes and symptoms of Acute Kidney Injury (AKI). Here, I’ll share how physicians treat and manage AKI, as well as what to expect. CRRT or intermittent hemodialysis? To treat AKI, nephrologists primarily use renal replacement therapy (RRT), which includes intermittent hemodialysis, peritoneal hemodialysis, various forms of CRRT, and “hybrid” therapies such as prolonged intermittent renal replacement therapy (PIRRT) or sustained low-efficiency hemodialysis (SLED). A few clinical trials are taking a look at CRRT and intermittent hemodialysis under different conditions.

27 08, 2019

Acute Kidney Injury (AKI): Why aggressive treatment early is a must

By |2020-02-07T10:36:05+00:00August 27th, 2019|Tags: , |

What is AKI? AKI is a sudden, reversible decline in the kidney’s glomerular filtration rate (GFR); in other words, its ability to filter metabolic waste. This kidney damage causes an elevation of serum urea and creatinine, which affects the body's ability to function properly. Most AKI cases are reversible. However, it's important to treat AKI as early as possible to avoid its progression to chronic kidney disease or kidney failure.

17 07, 2019

FSGS: A rare kidney disease without targeted therapies

By |2019-10-31T12:23:52+00:00July 17th, 2019|Tags: , |

Researchers are studying a few new and existing drugs to treat FSGS. FSGS needs a novel medication that regulates both high body fats and inflammasome inhibition via upstream innate immune system to block intracellular initiation of inflammatory cascade and extra cellular inflammation. Over the past five years, nearly 30% of Biorasi-initiated or ongoing studies involved chronic kidney disease. Our experience allows us to develop successful nephrology clinical trials.

27 12, 2016

Managing the Complexities of Clinical Trials in the Dialysis-Dependent CKD Population

By |2020-01-31T15:00:16+00:00December 27th, 2016|Tags: , |

Ensuring timely, quality, cost-effective execution of ESRD clinical trials requires a research organization to leverage the right people, processes, and technology infrastructure to overcome the trial complexities inherent in ESRD drug development. This white paper explores the complexities of running clinical trials in advanced CKD and the ESRD populations and looks at the solutions that can be employed to overcome challenges.

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